5l3q

X-ray diffraction
3.2Å resolution

Structure of the GTPase heterodimer of human SRP54 and SRalpha

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Signal recognition particle 54 kDa protein Chains: A, C
Molecule details ›
Chains: A, C
Length: 442 amino acids
Theoretical weight: 49.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61011 (Residues: 1-436; Coverage: 87%)
Gene name: SRP54
Sequence domains:
Structure domains:
Signal recognition particle receptor subunit alpha Chains: B, D
Molecule details ›
Chains: B, D
Length: 638 amino acids
Theoretical weight: 69.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08240 (Residues: 1-638; Coverage: 100%)
Gene names: SRPR, SRPRA
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: I23
Unit cell:
a: 241.394Å b: 241.394Å c: 241.394Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.148 0.145 0.19
Expression system: Escherichia coli