› › Structure analysis

LSD1-CoREST1 in complex with quinazoline-derivative reversible inhibitor

X-ray diffraction
2.8Å resolution
PDB entry 5l3e coloured by chain, front view.
PDB entry 5l3e coloured by chain, side view.
PDB entry 5l3e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: REST corepressor 1 and Lysine-specific histone demethylase 1A
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Multimeric state: hetero dimer
Accessible surface area: 38368.54 Å2
Buried surface area: 6933.33 Å2
Dissociation area: 2,663.36 Å2
Dissociation energy (ΔGdiss): 39.18 kcal/mol
Dissociation entropy (TΔSdiss): 13.94 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-129967

Macromolecules

Lysine-specific histone demethylase 1A
Chain: A
Length: 730 amino acids
Theoretical weight: 81.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60341 (Residues: 123-852; Coverage: 86%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Pfam:
InterPro:
CATH:
Lysine-specific histone demethylase 1A in PDB entry 5l3e, assembly 1, front view.
Lysine-specific histone demethylase 1A in PDB entry 5l3e, assembly 1, side view.
Lysine-specific histone demethylase 1A in PDB entry 5l3e, assembly 1, top view.
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REST corepressor 1
Chain: B
Length: 178 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UKL0 (Residues: 308-485; Coverage: 37%)
Gene names: KIAA0071, RCOR, RCOR1
Pfam:
InterPro:
CATH: Methane Monooxygenase Hydroxylase; Chain G, domain 1
REST corepressor 1 in PDB entry 5l3e, assembly 1, front view.
REST corepressor 1 in PDB entry 5l3e, assembly 1, side view.
REST corepressor 1 in PDB entry 5l3e, assembly 1, top view.
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