5l2w

X-ray diffraction
2.8Å resolution

The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:
G1/S-specific cyclin-E1 Chain: B
Molecule details ›
Chain: B
Length: 307 amino acids
Theoretical weight: 35.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24864 (Residues: 96-378; Coverage: 69%)
Gene names: CCNE, CCNE1
Sequence domains:
Structure domains: Cyclin-like

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P41212
Unit cell:
a: 100.307Å b: 100.307Å c: 151.857Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.246
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli