› 5l2s

X-ray diffraction
2.27Å resolution

The X-ray co-crystal structure of human CDK6 and Abemaciclib.

Released:
DOI: 10.2210/pdb5l2s/pdb
PDB entry 5l2s coloured by chain, front view.
PDB entry 5l2s coloured by chain, side view.
PDB entry 5l2s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.
Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW
Mol Cancer Ther 15 2273-2281 (2016)
PMID: 27496135

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 6 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00534 (Residues: 1-301; Coverage: 92%)
Gene names: CDK6, CDKN6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 6ZV 1 x 6ZV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4
Unit cell:
a: 102.17Å b: 102.17Å c: 59.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.249
Expression system: Spodoptera frugiperda

Quick links

Citations

47 review citations

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Zhong et al. (2021)
46 more

25 mentions without citation

Structural insights into the functional diversity of the CDK-cyclin family.
Wood et al. (2018)
24 more