PDBe 5l2i

X-ray diffraction
2.75Å resolution

The X-ray co-crystal structure of human CDK6 and Palbociclib.

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 6 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q00534 (Residues: 1-301; Coverage: 92%)
Gene names: CDK6, CDKN6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4
Unit cell:
a: 101.749Å b: 101.749Å c: 60.778Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.226 0.304
Expression system: Spodoptera frugiperda