PDBe 5l04

X-ray diffraction
2.1Å resolution

STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase JAK1 Chain: A
Molecule details ›
Chain: A
Length: 550 amino acids
Theoretical weight: 63.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23458 (Residues: 31-577; Coverage: 47%)
Gene names: JAK1, JAK1A, JAK1B
Sequence domains:
Interferon lambda receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 48 amino acids
Theoretical weight: 5.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IU57 (Residues: 260-307; Coverage: 10%)
Gene names: IFNLR1, IL28RA, LICR2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 165.7Å b: 53.8Å c: 87.39Å
α: 90° β: 114.72° γ: 90°
R-values:
R R work R free
0.171 0.169 0.23
Expression system: Escherichia coli