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Structure of the HCV1-C1 Antibody-Antigen Complex

X-ray diffraction
2.262Å resolution
PDB entry 5kzp coloured by chain, front view.
PDB entry 5kzp coloured by chain, side view.
PDB entry 5kzp coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Serine protease/helicase NS3 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 20526.04 Å2
Buried surface area: 5481.73 Å2
Dissociation area: 634.07 Å2
Dissociation energy (ΔGdiss): 6.89 kcal/mol
Dissociation entropy (TΔSdiss): 8.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210920
Assembly 2 (preferred)
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Assembly Name: Serine protease/helicase NS3 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 20699.96 Å2
Buried surface area: 5153.94 Å2
Dissociation area: 608.59 Å2
Dissociation energy (ΔGdiss): 3.37 kcal/mol
Dissociation entropy (TΔSdiss): 8.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210920
Assembly 3
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Assembly Name: Serine protease/helicase NS3 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 20420.46 Å2
Buried surface area: 5824.9 Å2
Dissociation area: 644.27 Å2
Dissociation energy (ΔGdiss): 8.88 kcal/mol
Dissociation entropy (TΔSdiss): 8.16 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210920
Assembly 4
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Assembly Name: Serine protease/helicase NS3 and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero trimer
Accessible surface area: 20582.26 Å2
Buried surface area: 5340.29 Å2
Dissociation area: 602.59 Å2
Dissociation energy (ΔGdiss): 2.79 kcal/mol
Dissociation entropy (TΔSdiss): 8.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-210920

Macromolecules

HCV1-C1 Antibody Fab Heavy Chain
Chains: E, F, G, H
Length: 226 amino acids
Theoretical weight: 24.58 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
HCV1-C1 Antibody Fab Heavy Chain in PDB entry 5kzp, assembly 2, front view.
HCV1-C1 Antibody Fab Heavy Chain in PDB entry 5kzp, assembly 2, side view.
HCV1-C1 Antibody Fab Heavy Chain in PDB entry 5kzp, assembly 2, top view.
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HCV1-C1 Antibody Fab Light Chain
Chains: I, J, K, L
Length: 213 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
InterPro:
CATH: Immunoglobulins
HCV1-C1 Antibody Fab Light Chain in PDB entry 5kzp, assembly 2, front view.
HCV1-C1 Antibody Fab Light Chain in PDB entry 5kzp, assembly 2, side view.
HCV1-C1 Antibody Fab Light Chain in PDB entry 5kzp, assembly 2, top view.
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Envelope glycoprotein E2
Chains: A, B, C, D
Length: 15 amino acids
Theoretical weight: 1.73 KDa
UniProt:
  • Canonical: P26663 (Residues: 412-423; Coverage: 0%)
Envelope glycoprotein E2 in PDB entry 5kzp, assembly 2, front view.
Envelope glycoprotein E2 in PDB entry 5kzp, assembly 2, side view.
Envelope glycoprotein E2 in PDB entry 5kzp, assembly 2, top view.
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