X-ray diffraction
3.21Å resolution

Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one


Function and Biology Details

Reaction catalysed:
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/threonine-protein kinase MARK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 40.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q7KZI7 (Residues: 39-364; Coverage: 41%)
Gene names: EMK1, MARK2
Sequence domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P61
Unit cell:
a: 120.416Å b: 120.416Å c: 99.457Å
α: 90° β: 90° γ: 120°
R R work R free
0.222 0.219 0.29
Expression system: Escherichia coli