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Crystal structure of USP7 catalytic domain [H294E] mutant in complex with ubiquitin

X-ray diffraction
1.97Å resolution
PDB entry 5kye coloured by chain, front view.
PDB entry 5kye coloured by chain, side view.
PDB entry 5kye coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 7 and Ubiquitin
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Multimeric state: hetero dimer
Accessible surface area: 18719.49 Å2
Buried surface area: 3989.09 Å2
Dissociation area: 1,984.44 Å2
Dissociation energy (ΔGdiss): 8.12 kcal/mol
Dissociation entropy (TΔSdiss): 11.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143285
Assembly 2
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Assembly Name: Ubiquitin carboxyl-terminal hydrolase 7 and Ubiquitin
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Multimeric state: hetero dimer
Accessible surface area: 17444.87 Å2
Buried surface area: 3473.5 Å2
Dissociation area: 1,736.75 Å2
Dissociation energy (ΔGdiss): 9.59 kcal/mol
Dissociation entropy (TΔSdiss): 11.51 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-143285

Macromolecules

Ubiquitin carboxyl-terminal hydrolase 7
Chains: A, B
Length: 351 amino acids
Theoretical weight: 40.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93009 (Residues: 208-554; Coverage: 32%)
Gene names: HAUSP, USP7
Pfam: Ubiquitin carboxyl-terminal hydrolase
InterPro:
CATH: ubp-family deubiquitinating enzyme superfamily
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5kye, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5kye, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 7 in PDB entry 5kye, assembly 1, top view.
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Ubiquitin
Chains: C, D
Length: 76 amino acids
Theoretical weight: 8.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0CG47 (Residues: 153-228; Coverage: 33%)
Gene name: UBB
Pfam: Ubiquitin family
InterPro:
Ubiquitin in PDB entry 5kye, assembly 1, front view.
Ubiquitin in PDB entry 5kye, assembly 1, side view.
Ubiquitin in PDB entry 5kye, assembly 1, top view.
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