X-ray diffraction
2.25Å resolution

Crystal Structure of a Pantoate-beta-alanine Ligase from Neisseria gonorrhoeae with bound AMPPNP

Entry author: Seattle Structural Genomics Center for Infectious Disease (SSGCID)

Function and Biology Details

Reaction catalysed:
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Pantothenate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.05 KDa
Source organism: Neisseria gonorrhoeae NCCP11945
Expression system: Escherichia coli
  • Canonical: B4RKE7 (Residues: 2-259; Coverage: 100%)
Gene names: NGK_0607, panC
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P41212
Unit cell:
a: 137.65Å b: 137.65Å c: 73.02Å
α: 90° β: 90° γ: 90°
R R work R free
0.185 0.183 0.219
Expression system: Escherichia coli