X-ray diffraction
2Å resolution

Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Apoptosis-inducing factor 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 543 amino acids
Theoretical weight: 59.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: O95831 (Residues: 78-613; Coverage: 87%)
  • Best match: O95831-4 (Residues: 78-322)
Gene names: AIF, AIFM1, PDCD8
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 64.623Å b: 81.802Å c: 108.323Å
α: 90° β: 90° γ: 90°
R R work R free
0.159 0.157 0.194
Expression system: Escherichia coli BL21(DE3)