5kv3

X-ray diffraction
1.7Å resolution

Human cyclophilin A at 278K, Data set 5

Released:
Source organism: Homo sapiens
Entry authors: Russi S, Gonzalez A, Kenner LR, Keedy DA, Fraser JS, van den Bedem H

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 2-165; Coverage: 99%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 42.949Å b: 52.612Å c: 89.245Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.155 0.201
Expression system: Escherichia coli