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Crystal structure of Pyrococcus horikoshii quinolinate synthase (NadA) with a bound Fe4S4 cluster

Source organism: Pyrococcus horikoshii OT3
Biochemical function: 4 iron, 4 sulfur cluster binding
Biological process: 'de novo' NAD biosynthetic process from aspartate
Cellular component: cytosol

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EC 2.5.1.72: Quinolinate synthase

Reaction catalysed:
Glycerone phosphate + iminosuccinate = pyridine-2,3-dicarboxylate + 2 H(2)O + phosphate
Systematic name:
Glycerone phosphate:iminosuccinate alkyltransferase (cyclizing)
Alternative Name(s):
  • NadA
  • QS
  • Quinolinate synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02445
Domain description: Quinolinate synthetase A protein
Occurring in:
  1. Quinolinate synthase
The deposited structure of PDB entry 5ktm contains 1 copy of Pfam domain PF02445 (Quinolinate synthetase A protein) in Quinolinate synthase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036094
Domain description: Quinolinate synthetase A superfamily
Occurring in:
  1. Quinolinate synthase
IPR003473
Domain description: Quinolinate synthetase A
Occurring in:
  1. Quinolinate synthase
IPR023066
Domain description: Quinolinate synthase A, type 2
Occurring in:
  1. Quinolinate synthase

Structure domain

CATH CATH domain
3.40.50.10800
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NadA-like
Occurring in:
  1. Quinolinate synthase
The deposited structure of PDB entry 5ktm contains 3 copies of CATH domain 3.40.50.10800 (Rossmann fold) in Quinolinate synthase. Showing 3 copies in chain A.

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