PDBe 5kr7

X-ray diffraction
1.9Å resolution

KDM4C bound to pyrazolo-pyrimidine scaffold


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Lysine-specific demethylase 4C Chains: A, B
Molecule details ›
Chains: A, B
Length: 367 amino acids
Theoretical weight: 42.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9H3R0 (Residues: 1-350; Coverage: 33%)
Gene names: GASC1, JHDM3C, JMJD2C, KDM4C, KIAA0780
Sequence domains:
Structure domains: Cupin

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 89.817Å b: 89.876Å c: 100.011Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.192 0.234
Expression system: Escherichia coli