X-ray diffraction
3.85Å resolution

Function and Biology Details

Reactions catalysed:
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
ATP-dependent translocase ABCB1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1248 amino acids
Theoretical weight: 137.79 KDa
Source organism: Mus musculus
Expression system: Komagataella phaffii GS115
  • Canonical: P21447 (Residues: 1-1276; Coverage: 97%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 97.52Å b: 116.439Å c: 375.052Å
α: 90° β: 90° γ: 90°
R R work R free
0.248 0.246 0.289
Expression system: Komagataella phaffii GS115