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Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase from Schistosoma mansoni in complex with cytosine and ribose-1-phosphate

X-ray diffraction
1.42Å resolution
PDB entry 5ko6 coloured by chain, front view.
PDB entry 5ko6 coloured by chain, side view.
PDB entry 5ko6 coloured by chain, top view.
Source organism: Schistosoma mansoni
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Purine nucleoside phosphorylase
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Multimeric state: homo trimer
Accessible surface area: 30341.6 Å2
Buried surface area: 9821.95 Å2
Dissociation area: 3,816.93 Å2
Dissociation energy (ΔGdiss): 49.96 kcal/mol
Dissociation entropy (TΔSdiss): 27.58 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-102740

Macromolecules

Purine nucleoside phosphorylase
Chain: A
Length: 287 amino acids
Theoretical weight: 31.36 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0U3AGT1 (Residues: 1-287; Coverage: 100%)
Pfam: Phosphorylase superfamily
InterPro:
CATH: Nucleoside phosphorylase domain
Purine nucleoside phosphorylase in PDB entry 5ko6, assembly 1, front view.
Purine nucleoside phosphorylase in PDB entry 5ko6, assembly 1, side view.
Purine nucleoside phosphorylase in PDB entry 5ko6, assembly 1, top view.
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