› 5kmc

X-ray diffraction
1.35Å resolution

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex

Released:
DOI: 10.2210/pdb5kmc/pdb
PDB 5kmc coloured by chain and viewed from the front.
PDB 5kmc coloured by chain and viewed from the side.
PDB 5kmc coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural Biology for Drug Design: Applications in Two Systems
Maize K
THESIS, University of Minnesota Digital Conservancy (2016)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine 5'-monophosphoramidase HINT1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49773 (Residues: 1-126; Coverage: 100%)
Gene names: HINT, HINT1, PKCI1, PRKCNH1
Sequence domains: HIT domain
Structure domains: HIT-like

Ligands and Environments

1 bound ligand:
Ligand 6UU 1 x 6UU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 78.093Å b: 46.151Å c: 63.994Å
α: 90° β: 94.66° γ: 90°
R-values:
R R work R free
0.159 0.158 0.174
Expression system: Escherichia coli

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