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Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III.

Esser L, Zhou F, Zhou Y, Xiao Y, Tang WK, Yu CA, Qin Z, Xia D
J Biol Chem 291 25019-25031 (2016)
Related entries: 5kkz, 5kli

Cited: 16 times
EuropePMC logo PMID: 27758861

Abstract

Complex III or the cytochrome (cyt) bc1 complex constitutes an integral part of the respiratory chain of most aerobic organisms and of the photosynthetic apparatus of anoxygenic purple bacteria. The function of cyt bc1 is to couple the reaction of electron transfer from ubiquinol to cytochrome c to proton pumping across the membrane. Mechanistically, the electron transfer reaction requires docking of its Rieske iron-sulfur protein (ISP) subunit to the quinol oxidation site (QP) of the complex. Formation of an H-bond between the ISP and the bound substrate was proposed to mediate the docking. Here we show that the binding of oxazolidinedione-type inhibitors famoxadone, jg144, and fenamidone induces docking of the ISP to the QP site in the absence of the H-bond formation both in mitochondrial and bacterial cyt bc1 complexes, demonstrating that ISP docking is independent of the proposed direct ISP-inhibitor interaction. The binding of oxazolidinedione-type inhibitors to cyt bc1 of different species reveals a toxophore that appears to interact optimally with residues in the QP site. The effect of modifications or additions to the toxophore on the binding to cyt bc1 from different species could not be predicted from structure-based sequence alignments, as demonstrated by the altered binding mode of famoxadone to bacterial cyt bc1.

Reviews - 5klv mentioned but not cited (1)

  1. Quinone binding sites of cyt bc complexes analysed by X-ray crystallography and cryogenic electron microscopy. Kao WC, Hunte C. Biochem Soc Trans 50 877-893 (2022)

Articles - 5klv mentioned but not cited (5)

  1. Mitochondrial complex III Rieske Fe-S protein processing and assembly. Fernandez-Vizarra E, Zeviani M. Cell Cycle 17 681-687 (2018)
  2. Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III. Esser L, Zhou F, Zhou Y, Xiao Y, Tang WK, Yu CA, Qin Z, Xia D. J Biol Chem 291 25019-25031 (2016)
  3. MitImpact 3: modeling the residue interaction network of the Respiratory Chain subunits. Castellana S, Biagini T, Petrizzelli F, Parca L, Panzironi N, Caputo V, Vescovi AL, Carella M, Mazza T. Nucleic Acids Res 49 D1282-D1288 (2021)
  4. Letter UQCRFS1N assembles mitochondrial respiratory complex-III into an asymmetric 21-subunit dimer. Zong S, Gu J, Liu T, Guo R, Wu M, Yang M. Protein Cell 9 586-591 (2018)
  5. Identification of immunodominant IgE epitopes of the major house dust mite allergen Der f 24. Cai ZL, Zhang Z, Luo WL, Hou YB, He YS, Chen JJ, Ji K. Int J Mol Med 44 1888-1898 (2019)


Reviews citing this publication (2)

  1. Catalytic Reactions and Energy Conservation in the Cytochrome bc1 and b6f Complexes of Energy-Transducing Membranes. Sarewicz M, Pintscher S, Pietras R, Borek A, Bujnowicz Ł, Hanke G, Cramer WA, Finazzi G, Osyczka A. Chem Rev 121 2020-2108 (2021)
  2. Review on Structures of Pesticide Targets. Li X, Yang X, Zheng X, Bai M, Hu D. Int J Mol Sci 21 E7144 (2020)

Articles citing this publication (8)

  1. Crystal structure of heme A synthase from Bacillus subtilis. Niwa S, Takeda K, Kosugi M, Tsutsumi E, Mogi T, Miki K. Proc Natl Acad Sci U S A 115 11953-11957 (2018)
  2. Transcriptomics and proteomic studies reveal acaricidal mechanism of octadecanoic acid-3, 4 - tetrahydrofuran diester against Sarcoptes scabiei var. cuniculi. Song X, Chen Z, Jia R, Cao M, Zou Y, Li L, Liang X, Yin L, He C, Yue G, Yin Z. Sci Rep 7 45479 (2017)
  3. Crystal structure of bacterial cytochrome bc 1 in complex with azoxystrobin reveals a conformational switch of the Rieske iron-sulfur protein subunit. Esser L, Zhou F, Yu CA, Xia D. J Biol Chem 294 12007-12019 (2019)
  4. Analysis of a Functional Dimer Model of Ubiquinol Cytochrome c Oxidoreductase. Bazil JN. Biophys J 113 1599-1612 (2017)
  5. Synthesis (Z) vs (E) Selectivity, Antifungal Activity against Fusarium oxysporum, and Structure-Based Virtual Screening of Novel Schiff Bases Derived from l-Tryptophan. Borrego-Muñoz P, Becerra LD, Ospina F, Coy-Barrera E, Quiroga D. ACS Omega 7 24714-24726 (2022)
  6. Structural modification of octadecanoic acid-3,4-tetrahydrofuran diester and the acaricidal activity and mechanism of its derivatives against Sarcoptes scabiei var. Cuniculi. Li L, Zhang Y, Liu T, Xing R, Peng S, Song X, Zou Y, Zhao X, Jia R, Wan H, Yin L, Ye G, Shi F, Zhang Y, Yue G, Yin Z. Front Pharmacol 13 953284 (2022)
  7. Structure of the bc1-cbb3 respiratory supercomplex from Pseudomonas aeruginosa. Di Trani JM, Gheorghita AA, Turner M, Brzezinski P, Ädelroth P, Vahidi S, Howell PL, Rubinstein JL. Proc Natl Acad Sci U S A 120 e2307093120 (2023)
  8. Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc1 complexes. Esser L, Zhou F, Zeher A, Wu W, Huang R, Yu CA, Lane KD, Wellems TE, Xia D. J Biol Chem 299 104860 (2023)


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