5kjl

X-ray diffraction
2.7Å resolution

SMYD2 in complex with AZ378

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-lysine methyltransferase SMYD2 Chain: A
Molecule details ›
Chain: A
Length: 429 amino acids
Theoretical weight: 49.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NRG4 (Residues: 5-433; Coverage: 99%)
Gene names: KMT3C, SMYD2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I4
Unit cell:
a: 155.098Å b: 155.098Å c: 52.553Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.172 0.236
Expression system: Escherichia coli