Function and Biology

p97 ND1-A232E in complex with VIMP

Source organism: Homo sapiens
Biochemical function: ATPase activity
Biological process: intracellular protein transport
Cellular component: integral component of endoplasmic reticulum membrane

EC 3.6.4.6: Vesicle-fusing ATPase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (vesicle-fusing)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02359
Domain description: Cell division protein 48 (CDC48), N-terminal domain
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of Pfam domain PF02359 (Cell division protein 48 (CDC48), N-terminal domain) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.

PF17862
Domain description: AAA+ lid domain
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of Pfam domain PF17862 (AAA+ lid domain) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.

PF00004
Domain description: ATPase family associated with various cellular activities (AAA)
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of Pfam domain PF00004 (ATPase family associated with various cellular activities (AAA)) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.

PF02933
Domain description: Cell division protein 48 (CDC48), domain 2
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of Pfam domain PF02933 (Cell division protein 48 (CDC48), domain 2) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.

InterPro InterPro annotations
IPR004201
Domain description: CDC48, domain 2
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR003338
Domain description: CDC48, N-terminal subdomain
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR041569
Domain description: AAA ATPase, AAA+ lid domain
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR003959
Domain description: ATPase, AAA-type, core
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR009010
Domain description: Aspartate decarboxylase-like domain superfamily
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR009703
Domain description: Selenoprotein S
Occurring in:
  1. Selenoprotein S
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR029067
Domain description: CDC48 domain 2-like superfamily
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Transitional endoplasmic reticulum ATPase

Structure domains

CATH CATH domains
3.10.330.10
Class: Alpha Beta
Architecture: Roll
Topology: Vcp-like ATPase; Chain A, domain 2
Homology: Vcp-like ATPase; Chain A, domain 2
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of CATH domain 3.10.330.10 (Vcp-like ATPase; Chain A, domain 2) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.
1.10.8.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helicase, Ruva Protein; domain 3
Homology: Helicase, Ruva Protein; domain 3
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of CATH domain 1.10.8.60 (Helicase, Ruva Protein; domain 3) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.
2.40.40.20
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Barwin-like endoglucanases
Homology: Barwin-like endoglucanases
Occurring in:
  1. Transitional endoplasmic reticulum ATPase
1 copy of CATH domain 2.40.40.20 (Barwin-like endoglucanases) in Transitional endoplasmic reticulum ATPase in PDB 5kiy.