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EBOV GP in complex with variable Fab domains of IgGs c2G4 and c13C6

Electron Microscopy
4.3Å resolution
PDB entry 5kel coloured by chain, front view.
PDB entry 5kel coloured by chain, side view.
PDB entry 5kel coloured by chain, top view.
Source organisms:
Assembly composition:
hetero octadecamer (preferred)
Entry contents: 6 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GP2 and IG-heavy chain and IG-light kappa chain and IG-heavy chain and IG-light kappa chain
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Multimeric state: hetero octadecamer
Accessible surface area: 104670.89 Å2
Buried surface area: 54258.11 Å2
Dissociation area: 4,923.21 Å2
Dissociation energy (ΔGdiss): -9.58 kcal/mol
Dissociation entropy (TΔSdiss): 74.35 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-211920

Macromolecules

GP1
Chains: A, E, F
Length: 469 amino acids
Theoretical weight: 50.97 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q05320 (Residues: 33-501; Coverage: 73%)
Gene name: GP
Pfam: Filovirus glycoprotein
InterPro:
GP1 in PDB entry 5kel, assembly 1, front view.
GP1 in PDB entry 5kel, assembly 1, side view.
GP1 in PDB entry 5kel, assembly 1, top view.
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GP2
Chains: B, G, I
Length: 143 amino acids
Theoretical weight: 16.14 KDa
Source organism: Ebola virus - Mayinga, Zaire, 1976
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q05320 (Residues: 502-637; Coverage: 21%)
Gene name: GP
GP2 in PDB entry 5kel, assembly 1, front view.
GP2 in PDB entry 5kel, assembly 1, side view.
GP2 in PDB entry 5kel, assembly 1, top view.
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c2G4 variable Fab domain heavy chain
Chains: H, P, Q
Length: 120 amino acids
Theoretical weight: 13.57 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana
InterPro:
c2G4 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, front view.
c2G4 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, side view.
c2G4 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, top view.
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c2G4 variable Fab domain light chain
Chains: L, T, U
Length: 107 amino acids
Theoretical weight: 11.64 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana
InterPro:
c2G4 variable Fab domain light chain in PDB entry 5kel, assembly 1, front view.
c2G4 variable Fab domain light chain in PDB entry 5kel, assembly 1, side view.
c2G4 variable Fab domain light chain in PDB entry 5kel, assembly 1, top view.
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c13C6 variable Fab domain heavy chain
Chains: C, J, M
Length: 121 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana
InterPro:
c13C6 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, front view.
c13C6 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, side view.
c13C6 variable Fab domain heavy chain in PDB entry 5kel, assembly 1, top view.
Molecule details ›

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c13C6 variable Fab domain light chain
Chains: D, N, O
Length: 107 amino acids
Theoretical weight: 11.61 KDa
Source organism: Homo sapiens
Expression system: Nicotiana benthamiana
InterPro:
c13C6 variable Fab domain light chain in PDB entry 5kel, assembly 1, front view.
c13C6 variable Fab domain light chain in PDB entry 5kel, assembly 1, side view.
c13C6 variable Fab domain light chain in PDB entry 5kel, assembly 1, top view.
Molecule details ›

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