› 5kcv

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RAC-alpha serine/threonine-protein kinase Chain: A
Molecule details ›
Chain: A
Length: 460 amino acids
Theoretical weight: 53.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P31749 (Residues: 2-446; Coverage: 93%)
Gene names: AKT1, PKB, RAC
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 6S1 1 x 6S1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 44.72Å b: 87.62Å c: 128.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.269
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors.
Arter et al. (2022)
7 more

8 mentions without citation

Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction.
Sarapultsev et al. (2018)
7 more