5ka6

X-ray diffraction
1.85Å resolution

HIV-1 gp41 variant Q552R and L555M resistance mutations

Released:
Entry authors: Bhardwaj A, Khasnis MD, Halkidis K, Root MJ

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transmembrane protein gp41 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 91 amino acids
Theoretical weight: 10.63 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: P04578 (Residues: 543-582, 625-661; Coverage: 9%)
Gene name: env
Sequence domains: Retroviral envelope protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P31
Unit cell:
a: 43.591Å b: 43.591Å c: 113.048Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.231 0.278
Expression system: Escherichia coli