Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine in mRNA
S-adenosyl-L-methionine + a 5-(N(7)-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N(7)-methyl 5-triphosphoguanosine)-N(6),2'-O-dimethyladenosine-[mRNA]
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183176 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N6-adenosine-methyltransferase catalytic subunit
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: MT-A70
Length: 225 amino acids
Theoretical weight: 25.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q86U44 (Residues: 357-580; Coverage: 39%)
Sequence domains: MT-A70
N6-adenosine-methyltransferase non-catalytic subunit
Molecule details ›
Chain: B
Length: 349 amino acids
Theoretical weight: 39.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: MT-A70
Length: 349 amino acids
Theoretical weight: 39.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q9HCE5 (Residues: 111-456; Coverage: 76%)
Sequence domains: MT-A70
