› 5k7h

X-ray diffraction
2.35Å resolution

Crystal structure of AibR in complex with the effector molecule isovaleryl coenzyme A

Released:
DOI: 10.2210/pdb5k7h/pdb
PDB entry 5k7h coloured by chain, front view.
PDB entry 5k7h coloured by chain, side view.
PDB entry 5k7h coloured by chain, top view.
Source organism: Myxococcus xanthus DK 1622
Primary publication:
The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.
Bock T, Volz C, Hering V, Scrima A, Müller R, Blankenfeldt W
Nucleic Acids Res 45 2166-2178 (2017)
PMID: 27940564

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 25.68 KDa
Source organism: Myxococcus xanthus DK 1622
Expression system: Escherichia coli
UniProt:
  • Canonical: Q1D4I5 (Residues: 1-228; Coverage: 100%)
Gene name: MXAN_4263
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NI 1 x NI
Ligand CL 4 x CL
Ligand IVC 2 x IVC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P61
Unit cell:
a: 89.78Å b: 89.78Å c: 132.118Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.192 0.235
Expression system: Escherichia coli

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Citations

2 review citations

Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures.
Housseini B Issa et al. (2018)
1 more

2 mentions without citation

The AibR-isovaleryl coenzyme A regulator and its DNA binding site - a model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus.
Bock et al. (2017)
1 more