› 5k79

X-ray diffraction
1.6Å resolution

Structure and anti-HIV activity of CYT-CVNH, a new cyanovirin-n homolog

Released:
DOI: 10.2210/pdb5k79/pdb
PDB 5k79 coloured by chain and viewed from the front.
PDB 5k79 coloured by chain and viewed from the side.
PDB 5k79 coloured by chain and viewed from the top.
Source organism: Cyanothece sp. PCC 7424
Primary publication:
Structure and Glycan Binding of a New Cyanovirin-N Homolog.
Matei E, Basu R, Furey W, Shi J, Calnan C, Aiken C, Gronenborn AM
J. Biol. Chem. (2016)
PMID: 27402833

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CVNH domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 11.94 KDa
Source organism: Cyanothece sp. PCC 7424
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B7KDN5 (Residues: 32-139; Coverage: 78%)
Gene name: PCC7424_1905
Sequence domains: CVNH domain

Ligands and Environments

2 bound ligands:
Ligand PEG 2 x PEG
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21212
Unit cell:
a: 93.84Å b: 74.396Å c: 36.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.233
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Natural Products from Cyanobacteria: Focus on Beneficial Activities.
Demay et al. (2019)
3 more