› 5k3n

X-ray diffraction
2.67Å resolution

Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209

Released:
DOI: 10.2210/pdb5k3n/pdb
PDB 5k3n coloured by chain and viewed from the front.
PDB 5k3n coloured by chain and viewed from the side.
PDB 5k3n coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Huang P, Rastinejad F, Lu J

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor ROR-gamma Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 247 amino acids
Theoretical weight: 28.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51449 (Residues: 265-507; Coverage: 47%)
Gene names: NR1F3, RORC, RORG, RZRG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand 6Q6 4 x 6Q6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P31
Unit cell:
a: 89.467Å b: 89.467Å c: 153.731Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.258 0.257 0.285
Expression system: Escherichia coli BL21(DE3)

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