X-ray diffraction
1.2Å resolution

Structure of the SH3 domain of MLK3 bound to peptide generated from phage display


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase kinase kinase 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 86 amino acids
Theoretical weight: 9.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q16584 (Residues: 41-105; Coverage: 8%)
Gene names: MAP3K11, MLK3, PTK1, SPRK
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P31
Unit cell:
a: 64Å b: 64Å c: 35.2Å
α: 90° β: 90° γ: 120°
R R work R free
0.139 0.137 0.168
Expression system: Escherichia coli