5jpv

X-ray diffraction
1.9Å resolution

Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Asialoglycoprotein receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 17.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4
UniProt:
  • Canonical: P07306 (Residues: 148-291; Coverage: 50%)
Gene names: ASGR1, CLEC4H1
Sequence domains: Lectin C-type domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 41.1Å b: 59.785Å c: 68.818Å
α: 90° β: 93.27° γ: 90°
R-values:
R R work R free
0.194 0.193 0.225
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpARG4