› 5jnr

X-ray diffraction
2Å resolution

Crystal structure of human low molecular weight protein tyrosine phosphatase (LMPTP) type A

Released:
DOI: 10.2210/pdb5jnr/pdb
PDB 5jnr coloured by chain and viewed from the front.
PDB 5jnr coloured by chain and viewed from the side.
PDB 5jnr coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N
Nat. Chem. Biol. (2017)
PMID: 28346406

Function and Biology Details

Reactions catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
A phosphate monoester + H(2)O = an alcohol + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P24666 (Residues: 1-158; Coverage: 100%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P212121
Unit cell:
a: 32.404Å b: 55.863Å c: 96.457Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.163 0.214
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

A Comprehensive Review of Receptor-Type Tyrosine-Protein Phosphatase Gamma (PTPRG) Role in Health and Non-Neoplastic Disease.
Boni et al. (2022)
7 more

2 mentions without citation

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.
Stanford et al. (2017)
1 more