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Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution

Source organisms:
Biochemical function: ATP binding
Biological process: protein localization to bicellular tight junction
Cellular component: basal body patch

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00022
Domain description: Actin
Occurring in:
  1. Actin, cytoplasmic 2
The deposited structure of PDB entry 5jlh contains 5 copies of Pfam domain PF00022 (Actin) in Actin, cytoplasmic 2. Showing 1 copy in chain A.

PF00435
Domain description: Spectrin repeat
Occurring in:
  1. Alpha-actinin A; Myosin-14
The deposited structure of PDB entry 5jlh contains 4 copies of Pfam domain PF00435 (Spectrin repeat) in Alpha-actinin A. Showing 2 copies in chain F (some of the copies are out of the observed residue ranges!).

PF00063
Domain description: Myosin head (motor domain)
Occurring in:
  1. Alpha-actinin A; Myosin-14
The deposited structure of PDB entry 5jlh contains 2 copies of Pfam domain PF00063 (Myosin head (motor domain)) in Alpha-actinin A. Showing 1 copy in chain F.

PF02736
Domain description: Myosin N-terminal SH3-like domain
Occurring in:
  1. Alpha-actinin A; Myosin-14
The deposited structure of PDB entry 5jlh contains 2 copies of Pfam domain PF02736 (Myosin N-terminal SH3-like domain) in Alpha-actinin A. Showing 1 copy in chain F.

InterPro InterPro annotations
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin, cytoplasmic 2
IPR001609
Domain description: Myosin head, motor domain
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR004001
Domain description: Actin, conserved site
Occurring in:
  1. Actin, cytoplasmic 2
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin, cytoplasmic 2
IPR018159
Domain description: Spectrin/alpha-actinin
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin, cytoplasmic 2
IPR002017
Domain description: Spectrin repeat
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR004009
Domain description: Myosin, N-terminal, SH3-like
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR036961
Domain description: Kinesin motor domain superfamily
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Alpha-actinin A; Myosin-14
IPR008989
Domain description: Myosin S1 fragment, N-terminal
Occurring in:
  1. Alpha-actinin A; Myosin-14

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin, cytoplasmic 2
The deposited structure of PDB entry 5jlh contains 10 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin, cytoplasmic 2. Showing 2 copies in chain A.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin, cytoplasmic 2
The deposited structure of PDB entry 5jlh contains 5 copies of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin, cytoplasmic 2. Showing 1 copy in chain A.

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