› 5jl7

X-ray diffraction
3.1Å resolution

HUMAN PLACENTAL AROMATASE CYTOCHROME P450 (CYP19A1): ANDROSTENEDIONE COMPLEX #3

Released:
DOI: 10.2210/pdb5jl7/pdb
PDB 5jl7 coloured by chain and viewed from the front.
PDB 5jl7 coloured by chain and viewed from the side.
PDB 5jl7 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Testosterone complex and non-steroidal ligands of human aromatase.
Ghosh D, Egbuta C, Lo J
J. Steroid Biochem. Mol. Biol. (2018)
PMID: 29476820

Function and Biology Details

Reaction catalysed: 
(1a) testosterone + [reduced NADPH--hemoprotein reductase] + O(2) = 19-hydroxytestosterone + H(2)O + [oxidized NADPH--hemoprotein reductase]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aromatase Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 57.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P11511 (Residues: 1-503; Coverage: 100%)
Gene names: ARO1, CYAR, CYP19, CYP19A1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments


Cofactor: Ligand HEM 1 x HEM
1 bound ligand:
Ligand ASD 1 x ASD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3221
Unit cell:
a: 140.333Å b: 140.333Å c: 118.958Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.185 0.207

Quick links

Citations

4 review citations

Reconsidering Aromatase for Breast Cancer Treatment: New Roles for an Old Target.
Caciolla et al. (2020)
3 more

1 mention without citation

Testosterone complex and non-steroidal ligands of human aromatase.
Ghosh et al. (2018)