PDBe 5jke

X-ray diffraction
2.86Å resolution

Crystal structure of human IZUMO1-JUNO complex (crystal form 3)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sperm-egg fusion protein Juno Chains: B, D
Molecule details ›
Chains: B, D
Length: 221 amino acids
Theoretical weight: 25.43 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: A6ND01 (Residues: 20-228; Coverage: 91%)
Gene names: FOLR4, IZUMO1R, JUNO
Sequence domains: Folate receptor family
Izumo sperm-egg fusion protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 246 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: Q8IYV9 (Residues: 22-255; Coverage: 71%)
  • Best match: Q8IYV9-2 (Residues: 22-169)
Gene name: IZUMO1
Sequence domains: Izumo-like Immunoglobulin domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NE3A
Unit cell:
a: 64.182Å b: 141.776Å c: 144.861Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.203 0.238
Expression system: Drosophila