› 5jiz

X-ray diffraction
1.5Å resolution

PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP

Released:
DOI: 10.2210/pdb5jiz/pdb
PDB entry 5jiz coloured by chain, front view.
PDB entry 5jiz coloured by chain, side view.
PDB entry 5jiz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Campbell JC, Kim CW

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13237 (Residues: 269-418; Coverage: 20%)
Gene names: PRKG2, PRKGR2
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand 6FW 2 x 6FW
Ligand MPD 2 x MPD
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 42.2Å b: 50.21Å c: 65.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.18 0.198
Expression system: Escherichia coli

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