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Crystal structure of the regulatory domain of the sodium driven chloride bicarbonate exchanger.

X-ray diffraction
2.801Å resolution
PDB entry 5jho coloured by chain, front view.
PDB entry 5jho coloured by chain, side view.
PDB entry 5jho coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Electroneutral sodium bicarbonate exchanger 1
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Multimeric state: homo dimer
Accessible surface area: 21920.99 Å2
Buried surface area: 1762.27 Å2
Dissociation area: 881.14 Å2
Dissociation energy (ΔGdiss): 3.99 kcal/mol
Dissociation entropy (TΔSdiss): 12.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-174131

Macromolecules

Electroneutral sodium bicarbonate exchanger 1
Chains: A, B
Length: 344 amino acids
Theoretical weight: 38.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2Y0W8 (Residues: 54-397; Coverage: 32%)
Gene names: KIAA0739, NBC, NBC3, NDCBE1, SLC4A8
Pfam: Band 3 cytoplasmic domain
InterPro:
Electroneutral sodium bicarbonate exchanger 1 in PDB entry 5jho, assembly 1, front view.
Electroneutral sodium bicarbonate exchanger 1 in PDB entry 5jho, assembly 1, side view.
Electroneutral sodium bicarbonate exchanger 1 in PDB entry 5jho, assembly 1, top view.
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