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Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11

X-ray diffraction
2.3Å resolution
PDB entry 5jhh coloured by chain, front view.
PDB entry 5jhh coloured by chain, side view.
PDB entry 5jhh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Rho guanine nucleotide exchange factor 11 and Transforming protein RhoA
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Multimeric state: hetero dimer
Accessible surface area: 25221.85 Å2
Buried surface area: 3604.65 Å2
Dissociation area: 1,609.94 Å2
Dissociation energy (ΔGdiss): 0.24 kcal/mol
Dissociation entropy (TΔSdiss): 13.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127285
Assembly 2 (preferred)
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Assembly Name: Rho guanine nucleotide exchange factor 11 and Transforming protein RhoA
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Multimeric state: hetero dimer
Accessible surface area: 25619.05 Å2
Buried surface area: 3185.62 Å2
Dissociation area: 1,473.83 Å2
Dissociation energy (ΔGdiss): 6.85 kcal/mol
Dissociation entropy (TΔSdiss): 13.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127285

Macromolecules

Rho guanine nucleotide exchange factor 11
Chains: A, E
Length: 369 amino acids
Theoretical weight: 42.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15085 (Residues: 714-1081; Coverage: 24%)
Gene names: ARHGEF11, KIAA0380
Pfam:
InterPro:
CATH:
Rho guanine nucleotide exchange factor 11 in PDB entry 5jhh, assembly 2, front view.
Rho guanine nucleotide exchange factor 11 in PDB entry 5jhh, assembly 2, side view.
Rho guanine nucleotide exchange factor 11 in PDB entry 5jhh, assembly 2, top view.
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Transforming protein RhoA
Chains: B, F
Length: 181 amino acids
Theoretical weight: 20.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61586 (Residues: 1-181; Coverage: 94%)
Gene names: ARH12, ARHA, RHO12, RHOA
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Transforming protein RhoA in PDB entry 5jhh, assembly 2, front view.
Transforming protein RhoA in PDB entry 5jhh, assembly 2, side view.
Transforming protein RhoA in PDB entry 5jhh, assembly 2, top view.
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