› 5jco

Electron Microscopy
4Å resolution

Structure and dynamics of single-isoform recombinant neuronal human tubulin

Released:
DOI: 10.2210/pdb5jco/pdb
PDB 5jco coloured by chain and viewed from the front.
PDB 5jco coloured by chain and viewed from the side.
PDB 5jco coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin.
Vemu A, Atherton J, Spector JO, Szyk A, Moores CA, Roll-Mecak A
OpenAccess logo J. Biol. Chem. (2016)
PMID: 27129203
Related structures: EMD-8150

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dodecamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tubulin beta-3 chain Chains: C, D, I, J, K, L
Molecule details ›
Chains: C, D, I, J, K, L
Length: 426 amino acids
Theoretical weight: 47.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13509 (Residues: 1-426; Coverage: 95%)
Gene names: TUBB3, TUBB4
Sequence domains:
Structure domains:
Tubulin alpha-1A chain Chains: A, B, E, F, G, H
Molecule details ›
Chains: A, B, E, F, G, H
Length: 437 amino acids
Theoretical weight: 48.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q71U36 (Residues: 1-437; Coverage: 97%)
Gene names: TUBA1A, TUBA3
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand G2P 6 x G2P
Ligand MG 12 x MG
Ligand GTP 6 x GTP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-8150
Expression system: Spodoptera frugiperda

Quick links

Citations

9 review citations

The mutational and phenotypic spectrum of TUBA1A-associated tubulinopathy.
Hebebrand et al. (2019)
8 more