› 5j69

X-ray diffraction
3.63Å resolution

Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Released:
DOI: 10.2210/pdb5j69/pdb
PDB entry 5j69 coloured by chain, front view.
PDB entry 5j69 coloured by chain, side view.
PDB entry 5j69 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Ni T, Harlos K, Gilbert R
Open Biol 6 (2016)
PMID: 27249642

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astrotactin-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.42 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75129 (Residues: 768-1033; Coverage: 21%)
Gene names: ASTN2, KIAA0634
Sequence domains: MAC/Perforin domain

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 98.7Å b: 86.6Å c: 108.36Å
α: 90° β: 111.74° γ: 90°
R-values:
R R work R free
0.281 0.28 0.302
Expression system: Homo sapiens

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Citations

5 review citations

Perforin-A key (shaped) weapon in the immunological arsenal.
Spicer et al. (2017)
4 more