Structure analysis

HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site

X-ray diffraction
2.789Å resolution
Source organism: HIV-1 M:B_HXB2R
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer

Binding statistics and energies are not available for this assembly

Macromolecules

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Chain: B
Length: 440 amino acids
Theoretical weight: 51.38 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04585 (Residues: 588-1027; Coverage: 31%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:

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Name: DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3')
Representative chains: P
Length: 22 nucleotides
Theoretical weight: 6.87 KDa

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Name: DNA (27-MER)
Representative chains: T
Length: 27 nucleotides
Theoretical weight: 8.41 KDa

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