› › Structure analysis

HIV-1 reverse transcriptase in complex with DNA that has incorporated a mismatched EFdA-MP at the N-(pre-translocation) site

X-ray diffraction
2.789Å resolution
PDB entry 5j2q coloured by chain, front view.
PDB entry 5j2q coloured by chain, side view.
PDB entry 5j2q coloured by chain, top view.
Source organism: HIV-1 M:B_HXB2R
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Protease and DNA
hide full assembly name
Multimeric state: hetero tetramer
Accessible surface area: 46507.83 Å2
Buried surface area: 13951.61 Å2
Dissociation area: 3,178.86 Å2
Dissociation energy (ΔGdiss): 27.37 kcal/mol
Dissociation entropy (TΔSdiss): 15.2 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-118855

Macromolecules

Reverse transcriptase/ribonuclease H
Chain: A
Length: 560 amino acids
Theoretical weight: 64.52 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04585 (Residues: 588-1147; Coverage: 39%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
Reverse transcriptase/ribonuclease H in PDB entry 5j2q, assembly 1, front view.
Reverse transcriptase/ribonuclease H in PDB entry 5j2q, assembly 1, side view.
Reverse transcriptase/ribonuclease H in PDB entry 5j2q, assembly 1, top view.
Molecule details ›

Search similar proteins

p51 RT
Chain: B
Length: 440 amino acids
Theoretical weight: 51.38 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04585 (Residues: 588-1027; Coverage: 31%)
Gene name: gag-pol
Pfam:
InterPro:
CATH:
p51 RT in PDB entry 5j2q, assembly 1, front view.
p51 RT in PDB entry 5j2q, assembly 1, side view.
p51 RT in PDB entry 5j2q, assembly 1, top view.
Molecule details ›

Search similar proteins

DNA chain P
Name: DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3')
Representative chains: P
Length: 22 nucleotides
Theoretical weight: 6.87 KDa
DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3') in PDB entry 5j2q, assembly 1, front view.
DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3') in PDB entry 5j2q, assembly 1, side view.
DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(6FM)P*(6FM))-3') in PDB entry 5j2q, assembly 1, top view.
Molecule details ›

Search similar DNA

DNA chain T
Name: DNA (27-MER)
Representative chains: T
Length: 27 nucleotides
Theoretical weight: 8.41 KDa
DNA (27-MER) in PDB entry 5j2q, assembly 1, front view.
DNA (27-MER) in PDB entry 5j2q, assembly 1, side view.
DNA (27-MER) in PDB entry 5j2q, assembly 1, top view.
Molecule details ›

Search similar DNA

Quick links