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Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution

Source organism: Mycobacterium tuberculosis
Biochemical function: protein binding
Biological process: response to antibiotic
Cellular component: cytosol

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF21313
Domain description: Transcriptional regulator EthR, C-terminal domain
Occurring in:
  1. HTH-type transcriptional regulator EthR
The deposited structure of PDB entry 5j1y contains 1 copy of Pfam domain PF21313 (Transcriptional regulator EthR, C-terminal domain) in HTH-type transcriptional regulator EthR. Showing 1 copy in chain A.

PF00440
Domain description: Bacterial regulatory proteins, tetR family
Occurring in:
  1. HTH-type transcriptional regulator EthR
The deposited structure of PDB entry 5j1y contains 1 copy of Pfam domain PF00440 (Bacterial regulatory proteins, tetR family) in HTH-type transcriptional regulator EthR. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001647
Domain description: DNA-binding HTH domain, TetR-type
Occurring in:
  1. HTH-type transcriptional regulator EthR
IPR036271
Domain description: Tetracyclin repressor-like, C-terminal domain superfamily
Occurring in:
  1. HTH-type transcriptional regulator EthR
IPR009057
Domain description: Homeobox-like domain superfamily
Occurring in:
  1. HTH-type transcriptional regulator EthR

Structure domains

CATH CATH domains
1.10.357.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Tetracycline Repressor; domain 2
Homology: Tetracycline Repressor, domain 2
Occurring in:
  1. HTH-type transcriptional regulator EthR
The deposited structure of PDB entry 5j1y contains 1 copy of CATH domain 1.10.357.10 (Tetracycline Repressor; domain 2) in HTH-type transcriptional regulator EthR. Showing 1 copy in chain A.
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. HTH-type transcriptional regulator EthR
The deposited structure of PDB entry 5j1y contains 1 copy of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in HTH-type transcriptional regulator EthR. Showing 1 copy in chain A.

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