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Human holo-PIC in the closed state

Source organism: Homo sapiens
Biochemical function: protein binding
Biological process: transcription by RNA polymerase II
Cellular component: nucleoplasm

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EC 3.6.4.12: DNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (DNA helix unwinding)
Alternative Name(s):
  • 3' to 5' DNA helicase
  • 3'-5' DNA helicase
  • 3'-5' PfDH
  • 5' to 3' DNA helicase
  • AvDH1
  • BACH1 helicase
  • BLM protein
  • BRCA1-associated C-terminal helicase
  • BcMCM
  • CeWRN-1
  • DNA helicase 120
  • DNA helicase A
  • DNA helicase E
  • DNA helicase II
  • DNA helicase III
  • DNA helicase RECQL5'
  • DNA helicase VI
  • Dbp9p
  • DmRECQ5
  • DnaB
  • DnaB helicase E1
  • HHcsA
  • HPif1
  • Hel E
  • Helicase DnaB
  • Helicase HDH IV
  • Helicase domain of bacteriophage T7 gene 4 protein helicase
  • Hmi1p
  • MCM helicase
  • MCM protein
  • MER3 helicase
  • MER3 protein
  • MPH1
  • PDH120
  • PIF1
  • PcrA
  • PcrA helicase
  • PfDH A
  • Pfh1p
  • UvrD

EC 2.7.7.6: DNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • C RNA formation factors
  • C ribonucleic acid formation factors
  • DNA-dependent RNA nucleotidyltransferase
  • DNA-dependent RNA polymerase
  • DNA-dependent ribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid-dependent ribonucleic acid polymerase
  • RNA nucleotidyltransferase
  • RNA nucleotidyltransferase (DNA-directed)
  • RNA polymerase
  • RNA polymerase I
  • RNA polymerase II
  • RNA polymerase III
  • RNA transcriptase
  • Ribonucleate nucleotidyltransferase
  • Ribonucleate polymerase
  • Ribonucleic acid nucleotidyltransferase
  • Ribonucleic acid polymerase
  • Ribonucleic acid transcriptase
  • Ribonucleic polymerase
  • Ribonucleic transcriptase
  • Transcriptase

EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF05001
Domain description: RNA polymerase Rpb1 C-terminal repeat
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 42 copies of Pfam domain PF05001 (RNA polymerase Rpb1 C-terminal repeat) in DNA-directed RNA polymerase II subunit RPB1. Showing 42 copies in chain A (this domain is out of the observed residue ranges!).

PF00352
Domain description: Transcription factor TFIID (or TATA-binding protein, TBP)
Occurring in:
  1. TATA-box-binding protein
The deposited structure of PDB entry 5iy6 contains 2 copies of Pfam domain PF00352 (Transcription factor TFIID (or TATA-binding protein, TBP)) in TATA-box-binding protein. Showing 2 copies in chain P.

PF03153
Domain description: Transcription factor IIA, alpha/beta subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 1
The deposited structure of PDB entry 5iy6 contains 2 copies of Pfam domain PF03153 (Transcription factor IIA, alpha/beta subunit) in Transcription initiation factor IIA subunit 1. Showing 2 copies in chain N.

PF00382
Domain description: Transcription factor TFIIB repeat
Occurring in:
  1. Transcription initiation factor IIB
The deposited structure of PDB entry 5iy6 contains 2 copies of Pfam domain PF00382 (Transcription factor TFIIB repeat) in Transcription initiation factor IIB. Showing 2 copies in chain M.

PF08271
Domain description: TFIIB zinc-binding
Occurring in:
  1. Transcription initiation factor IIB
  2. General transcription factor IIE subunit 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF08271 (TFIIB zinc-binding) in Transcription initiation factor IIB. Showing 1 copy in chain M.
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF08271 (TFIIB zinc-binding) in General transcription factor IIE subunit 1. Showing 1 copy in chain Q.

PF01096
Domain description: Transcription factor S-II (TFIIS)
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
  2. Transcription elongation factor A protein 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01096 (Transcription factor S-II (TFIIS)) in DNA-directed RNA polymerase II subunit RPB9. Showing 1 copy in chain I.
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01096 (Transcription factor S-II (TFIIS)) in Transcription elongation factor A protein 1. Showing 1 copy in chain U.

PF01193
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
  2. DNA-directed RNA polymerase II subunit RPB11-a
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain C.

PF13307
Domain description: Helicase C-terminal domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF13307 (Helicase C-terminal domain) in General transcription and DNA repair factor IIH helicase subunit XPD. Showing 1 copy in chain W.

PF06777
Domain description: Helical and beta-bridge domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF06777 (Helical and beta-bridge domain) in General transcription and DNA repair factor IIH helicase subunit XPD. Showing 1 copy in chain W.

PF06733
Domain description: DEAD_2
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF06733 (DEAD_2) in General transcription and DNA repair factor IIH helicase subunit XPD. Showing 1 copy in chain W.

PF16203
Domain description: ERCC3/RAD25/XPB C-terminal helicase
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF16203 (ERCC3/RAD25/XPB C-terminal helicase) in General transcription and DNA repair factor IIH helicase subunit XPB. Showing 1 copy in chain V.

PF04851
Domain description: Type III restriction enzyme, res subunit
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04851 (Type III restriction enzyme, res subunit) in General transcription and DNA repair factor IIH helicase subunit XPB. Showing 1 copy in chain V.

PF13625
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF13625 (Helicase conserved C-terminal domain) in General transcription and DNA repair factor IIH helicase subunit XPB. Showing 1 copy in chain V (this domain is out of the observed residue ranges!).

PF07500
Domain description: Transcription factor S-II (TFIIS), central domain
Occurring in:
  1. Transcription elongation factor A protein 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF07500 (Transcription factor S-II (TFIIS), central domain) in Transcription elongation factor A protein 1. Showing 1 copy in chain U.

PF08711
Domain description: TFIIS helical bundle-like domain
Occurring in:
  1. Transcription elongation factor A protein 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF08711 (TFIIS helical bundle-like domain) in Transcription elongation factor A protein 1. Showing 1 copy in chain U (this domain is out of the observed residue ranges!).

PF02270
Domain description: TFIIF, beta subunit HTH domain
Occurring in:
  1. General transcription factor IIF subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02270 (TFIIF, beta subunit HTH domain) in General transcription factor IIF subunit 2. Showing 1 copy in chain T.

PF17683
Domain description: TFIIF, beta subunit N-terminus
Occurring in:
  1. General transcription factor IIF subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF17683 (TFIIF, beta subunit N-terminus) in General transcription factor IIF subunit 2. Showing 1 copy in chain T.

PF05793
Domain description: Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
Occurring in:
  1. General transcription factor IIF subunit 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF05793 (Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)) in General transcription factor IIF subunit 1. Showing 1 copy in chain S.

PF18121
Domain description: TFA2 Winged helix domain 2
Occurring in:
  1. Transcription initiation factor IIE subunit beta
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF18121 (TFA2 Winged helix domain 2) in Transcription initiation factor IIE subunit beta. Showing 1 copy in chain R.

PF02186
Domain description: TFIIE beta subunit core domain
Occurring in:
  1. Transcription initiation factor IIE subunit beta
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02186 (TFIIE beta subunit core domain) in Transcription initiation factor IIE subunit beta. Showing 1 copy in chain R.

PF11521
Domain description: C-terminal general transcription factor TFIIE alpha
Occurring in:
  1. General transcription factor IIE subunit 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF11521 (C-terminal general transcription factor TFIIE alpha) in General transcription factor IIE subunit 1. Showing 1 copy in chain Q (this domain is out of the observed residue ranges!).

PF02002
Domain description: TFIIE alpha subunit
Occurring in:
  1. General transcription factor IIE subunit 1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02002 (TFIIE alpha subunit) in General transcription factor IIE subunit 1. Showing 1 copy in chain Q.

PF02751
Domain description: Transcription initiation factor IIA, gamma subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02751 (Transcription initiation factor IIA, gamma subunit) in Transcription initiation factor IIA subunit 2. Showing 1 copy in chain O.

PF02268
Domain description: Transcription initiation factor IIA, gamma subunit, helical domain
Occurring in:
  1. Transcription initiation factor IIA subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02268 (Transcription initiation factor IIA, gamma subunit, helical domain) in Transcription initiation factor IIA subunit 2. Showing 1 copy in chain O.

PF03604
Domain description: DNA directed RNA polymerase, 7 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03604 (DNA directed RNA polymerase, 7 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC4. Showing 1 copy in chain L.

PF13656
Domain description: RNA polymerase Rpb3/Rpb11 dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11-a
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF13656 (RNA polymerase Rpb3/Rpb11 dimerisation domain) in DNA-directed RNA polymerase II subunit RPB11-a. Showing 1 copy in chain K.

PF01194
Domain description: RNA polymerases N / 8 kDa subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01194 (RNA polymerases N / 8 kDa subunit) in DNA-directed RNA polymerases I, II, and III subunit RPABC5. Showing 1 copy in chain J.

PF02150
Domain description: RNA polymerases M/15 Kd subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF02150 (RNA polymerases M/15 Kd subunit) in DNA-directed RNA polymerase II subunit RPB9. Showing 1 copy in chain I.

PF03870
Domain description: RNA polymerase Rpb8
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03870 (RNA polymerase Rpb8) in DNA-directed RNA polymerases I, II, and III subunit RPABC3. Showing 1 copy in chain H.

PF00575
Domain description: S1 RNA binding domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF00575 (S1 RNA binding domain) in DNA-directed RNA polymerase II subunit RPB7. Showing 1 copy in chain G.

PF03876
Domain description: SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03876 (SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397) in DNA-directed RNA polymerase II subunit RPB7. Showing 1 copy in chain G.

PF01192
Domain description: RNA polymerase Rpb6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01192 (RNA polymerase Rpb6) in DNA-directed RNA polymerases I, II, and III subunit RPABC2. Showing 1 copy in chain F.

PF01191
Domain description: RNA polymerase Rpb5, C-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01191 (RNA polymerase Rpb5, C-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain E.

PF03871
Domain description: RNA polymerase Rpb5, N-terminal domain
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03871 (RNA polymerase Rpb5, N-terminal domain) in DNA-directed RNA polymerases I, II, and III subunit RPABC1. Showing 1 copy in chain E.

PF03874
Domain description: RNA polymerase Rpb4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03874 (RNA polymerase Rpb4) in DNA-directed RNA polymerase II subunit RPB4. Showing 1 copy in chain D.

PF01000
Domain description: RNA polymerase Rpb3/RpoA insert domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF01000 (RNA polymerase Rpb3/RpoA insert domain) in DNA-directed RNA polymerase II subunit RPB3. Showing 1 copy in chain C.

PF04560
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04560 (RNA polymerase Rpb2, domain 7) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF00562
Domain description: RNA polymerase Rpb2, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF00562 (RNA polymerase Rpb2, domain 6) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04567
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04567 (RNA polymerase Rpb2, domain 5) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04566
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04566 (RNA polymerase Rpb2, domain 4) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04565
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04565 (RNA polymerase Rpb2, domain 3) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04561
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04561 (RNA polymerase Rpb2, domain 2) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04563
Domain description: RNA polymerase beta subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04563 (RNA polymerase beta subunit) in DNA-directed RNA polymerase II subunit RPB2. Showing 1 copy in chain B.

PF04990
Domain description: RNA polymerase Rpb1, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04990 (RNA polymerase Rpb1, domain 7) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF04992
Domain description: RNA polymerase Rpb1, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04992 (RNA polymerase Rpb1, domain 6) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF04998
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04998 (RNA polymerase Rpb1, domain 5) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF05000
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF05000 (RNA polymerase Rpb1, domain 4) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF04983
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04983 (RNA polymerase Rpb1, domain 3) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF00623
Domain description: RNA polymerase Rpb1, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF00623 (RNA polymerase Rpb1, domain 2) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF04997
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04997 (RNA polymerase Rpb1, domain 1) in DNA-directed RNA polymerase II subunit RPB1. Showing 1 copy in chain A.

PF03850
Domain description: Transcription factor Tfb4
Occurring in:
  1. General transcription factor IIH subunit 3
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03850 (Transcription factor Tfb4) in General transcription factor IIH subunit 3. Showing 1 copy in chain AA [auth 3].

PF18307
Domain description: Transcription factor Tfb2 (p52) C-terminal domain
Occurring in:
  1. General transcription factor IIH subunit 4
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF18307 (Transcription factor Tfb2 (p52) C-terminal domain) in General transcription factor IIH subunit 4. Showing 1 copy in chain Z [auth 2].

PF03849
Domain description: Transcription factor Tfb2
Occurring in:
  1. General transcription factor IIH subunit 4
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF03849 (Transcription factor Tfb2) in General transcription factor IIH subunit 4. Showing 1 copy in chain Z [auth 2].

PF06331
Domain description: Transcription factor TFIIH complex subunit Tfb5
Occurring in:
  1. General transcription factor IIH subunit 5
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF06331 (Transcription factor TFIIH complex subunit Tfb5) in General transcription factor IIH subunit 5. Showing 1 copy in chain Y [auth 1].

PF07975
Domain description: TFIIH C1-like domain
Occurring in:
  1. General transcription factor IIH subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF07975 (TFIIH C1-like domain) in General transcription factor IIH subunit 2. Showing 1 copy in chain X [auth 0] (this domain is out of the observed residue ranges!).

PF04056
Domain description: Ssl1-like
Occurring in:
  1. General transcription factor IIH subunit 2
The deposited structure of PDB entry 5iy6 contains 1 copy of Pfam domain PF04056 (Ssl1-like) in General transcription factor IIH subunit 2. Showing 1 copy in chain X [auth 0].

InterPro InterPro annotations
IPR000684
Domain description: RNA polymerase II, heptapeptide repeat, eukaryotic
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR000814
Domain description: TATA-box binding protein
Occurring in:
  1. TATA-box-binding protein
IPR001945
Domain description: RAD3/XPD family
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR000812
Domain description: Transcription factor TFIIB
Occurring in:
  1. Transcription initiation factor IIB
IPR001222
Domain description: Zinc finger, TFIIS-type
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
  2. Transcription elongation factor A protein 1
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  2. General transcription and DNA repair factor IIH helicase subunit XPD
IPR009088
Domain description: Transcription factor IIA, beta-barrel
Occurring in:
  1. Transcription initiation factor IIA subunit 1
  2. Transcription initiation factor IIA subunit 2
IPR004855
Domain description: Transcription factor IIA, alpha/beta subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 1
IPR005570
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC3
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
  2. DNA-directed RNA polymerases I, II, and III subunit RPABC3
IPR036603
Domain description: RNA polymerase, RBP11-like subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
  2. DNA-directed RNA polymerase II subunit RPB11-a
IPR003618
Domain description: Transcription elongation factor S-II, central domain
Occurring in:
  1. Transcription elongation factor A protein 1
IPR011039
Domain description: Transcription Factor IIF, Rap30/Rap74, interaction
Occurring in:
  1. General transcription factor IIF subunit 1
  2. General transcription factor IIF subunit 2
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. Transcription initiation factor IIE subunit beta
  2. General transcription factor IIF subunit 1
  3. General transcription factor IIF subunit 2
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Transcription initiation factor IIE subunit beta
  2. General transcription factor IIF subunit 1
  3. General transcription factor IIF subunit 2
IPR003166
Domain description: Transcription factor TFIIE beta subunit, DNA-binding domain
Occurring in:
  1. Transcription initiation factor IIE subunit beta
IPR013137
Domain description: Zinc finger, TFIIB-type
Occurring in:
  1. Transcription initiation factor IIB
  2. General transcription factor IIE subunit 1
IPR000268
Domain description: DNA-directed RNA polymerase subunit RPABC5/Rpb10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR014381
Domain description: DNA-directed RNA polymerase subunit Rpo5/Rpb5
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR004600
Domain description: TFIIH subunit Tfb4/GTF2H3
Occurring in:
  1. General transcription factor IIH subunit 3
IPR004598
Domain description: Transcription factor TFIIH subunit p52/Tfb2
Occurring in:
  1. General transcription factor IIH subunit 4
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. General transcription factor IIH subunit 2
  2. General transcription factor IIH subunit 3
IPR006555
Domain description: ATP-dependent helicase, C-terminal
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR036575
Domain description: Transcription elongation factor S-II, central domain superfamily
Occurring in:
  1. Transcription elongation factor A protein 1
IPR017923
Domain description: Transcription factor IIS, N-terminal
Occurring in:
  1. Transcription elongation factor A protein 1
IPR035441
Domain description: TFIIS/LEDGF domain superfamily
Occurring in:
  1. Transcription elongation factor A protein 1
IPR003196
Domain description: Transcription initiation factor IIF, beta subunit
Occurring in:
  1. General transcription factor IIF subunit 2
IPR008851
Domain description: Transcription initiation factor IIF, alpha subunit
Occurring in:
  1. General transcription factor IIF subunit 1
IPR016656
Domain description: Transcription initiation factor TFIIE, beta subunit
Occurring in:
  1. Transcription initiation factor IIE subunit beta
IPR012295
Domain description: TBP domain superfamily
Occurring in:
  1. TATA-box-binding protein
IPR015871
Domain description: Transcription initiation factor IIA, gamma subunit, C-terminal
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR015872
Domain description: Transcription initiation factor IIA, gamma subunit, N-terminal
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR023486
Domain description: Transcription factor TFIIB, conserved site
Occurring in:
  1. Transcription initiation factor IIB
IPR013763
Domain description: Cyclin-like domain
Occurring in:
  1. Transcription initiation factor IIB
IPR036915
Domain description: Cyclin-like superfamily
Occurring in:
  1. Transcription initiation factor IIB
IPR013150
Domain description: Transcription factor TFIIB, cyclin-like domain
Occurring in:
  1. Transcription initiation factor IIB
IPR006591
Domain description: RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR001529
Domain description: DNA-directed RNA polymerase, M/15kDa subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR012164
Domain description: DNA-directed RNA polymerase subunit/transcription factor S
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR036898
Domain description: RNA polymerase Rpb7-like, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
IPR006110
Domain description: RNA polymerase, subunit omega/Rpo6/RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR036161
Domain description: RPB6/omega subunit-like superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR035913
Domain description: RPB5-like RNA polymerase subunit superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR036710
Domain description: RNA polymerase Rpb5, N-terminal domain superfamily
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR036643
Domain description: DNA-directed RNA polymerase, insert domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR011263
Domain description: DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR015712
Domain description: DNA-directed RNA polymerase, subunit 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR044893
Domain description: RNA polymerase Rpb1, clamp domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR035935
Domain description: TFB5-like superfamily
Occurring in:
  1. General transcription factor IIH subunit 5
IPR009400
Domain description: TFIIH subunit TTDA/Tfb5
Occurring in:
  1. General transcription factor IIH subunit 5
IPR004595
Domain description: TFIIH C1-like domain
Occurring in:
  1. General transcription factor IIH subunit 2
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. General transcription factor IIH subunit 2
  2. General transcription factor IIE subunit 1
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. General transcription factor IIH subunit 2
IPR007198
Domain description: Ssl1-like
Occurring in:
  1. General transcription factor IIH subunit 2
IPR012170
Domain description: TFIIH subunit Ssl1/p44
Occurring in:
  1. General transcription factor IIH subunit 2
IPR010643
Domain description: Helical and beta-bridge domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR002464
Domain description: DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR010614
Domain description: RAD3-like helicase, DEAD
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR013020
Domain description: ATP-dependent helicase Rad3/Chl1-like
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR006554
Domain description: Helicase-like, DEXD box c2 type
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR045028
Domain description: Helicase superfamily 1/2, DinG/Rad3-like
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR014013
Domain description: Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type
Occurring in:
  1. General transcription and DNA repair factor IIH helicase subunit XPD
IPR032438
Domain description: ERCC3/RAD25/XPB helicase, C-terminal domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR006935
Domain description: Helicase/UvrB, N-terminal
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR032830
Domain description: Helicase XPB/Ssl2, N-terminal domain
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR001161
Domain description: Helicase XPB/Ssl2
Occurring in:
  1. General transcription and DNA repair factor IIH helicase/translocase subunit XPB
IPR003617
Domain description: Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
Occurring in:
  1. Transcription elongation factor A protein 1
IPR006289
Domain description: Transcription elongation factor, TFIIS
Occurring in:
  1. Transcription elongation factor A protein 1
IPR035100
Domain description: Transcription elongation factor, IIS-type
Occurring in:
  1. Transcription elongation factor A protein 1
IPR040450
Domain description: TFIIF beta subunit, HTH domain
Occurring in:
  1. General transcription factor IIF subunit 2
IPR040504
Domain description: TFIIF, beta subunit, N-terminal
Occurring in:
  1. General transcription factor IIF subunit 2
IPR040501
Domain description: TFA2, Winged helix domain 2
Occurring in:
  1. Transcription initiation factor IIE subunit beta
IPR021600
Domain description: Transcription factor TFIIE alpha subunit, C-terminal
Occurring in:
  1. General transcription factor IIE subunit 1
IPR002853
Domain description: Transcription initiation factor IIE subunit alpha, N-terminal
Occurring in:
  1. General transcription factor IIE subunit 1
IPR024550
Domain description: TFIIEalpha/SarR/Rpc3 HTH domain
Occurring in:
  1. General transcription factor IIE subunit 1
IPR017919
Domain description: Transcription factor TFE/TFIIEalpha HTH domain
Occurring in:
  1. General transcription factor IIE subunit 1
IPR039997
Domain description: Transcription factor E
Occurring in:
  1. General transcription factor IIE subunit 1
IPR030491
Domain description: TATA-box binding protein, conserved site
Occurring in:
  1. TATA-box-binding protein
IPR033710
Domain description: TATA-box binding protein, eukaryotic
Occurring in:
  1. TATA-box-binding protein
IPR009083
Domain description: Transcription factor IIA, alpha-helical domain
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR003194
Domain description: Transcription initiation factor IIA, gamma subunit
Occurring in:
  1. Transcription initiation factor IIA subunit 2
IPR029040
Domain description: RNA polymerase subunit RPABC4/transcription elongation factor Spt4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR039747
Domain description: DNA-directed RNA polymerases I, II, and III subunit RPABC4
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC4
IPR008193
Domain description: DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11-a
IPR009025
Domain description: DNA-directed RNA polymerase, RBP11-like dimerisation domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11-a
IPR022905
Domain description: DNA-directed RNA polymerase subunit Rpo11-like
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11-a
IPR037685
Domain description: RNA polymerase RBP11
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB11-a
IPR020789
Domain description: RNA polymerases, subunit N, zinc binding site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR023580
Domain description: RNA polymerase subunit RPB10
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC5
IPR034012
Domain description: Pol II subunit B9, C-terminal zinc ribbon
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR019761
Domain description: DNA-directed RNA polymerase M, 15kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB9
IPR003029
Domain description: S1 domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
IPR005576
Domain description: RNA polymerase Rpb7-like , N-terminal
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
IPR045113
Domain description: RNA polymerase subunit Rpb7-like
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB7
IPR020708
Domain description: DNA-directed RNA polymerase, 14-18kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR028363
Domain description: DNA-directed RNA polymerase, subunit RPB6
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR006111
Domain description: Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC2
IPR020608
Domain description: RNA polymerase, subunit H/Rpb5, conserved site
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR000783
Domain description: RNA polymerase, subunit H/Rpb5 C-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR005571
Domain description: RNA polymerase, Rpb5, N-terminal
Occurring in:
  1. DNA-directed RNA polymerases I, II, and III subunit RPABC1
IPR005574
Domain description: RNA polymerase subunit Rpb4/RPC9
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
IPR006590
Domain description: RNA polymerase Rpb4/RPC9, core
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
IPR038324
Domain description: Rpb4/RPC9 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
IPR045222
Domain description: DNA-directed RNA polymerase II subunit Rpb4-like
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
IPR010997
Domain description: HRDC-like superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB4
IPR011262
Domain description: DNA-directed RNA polymerase, insert domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR001514
Domain description: DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR022842
Domain description: DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB3
IPR007641
Domain description: RNA polymerase Rpb2, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007121
Domain description: RNA polymerase, beta subunit, conserved site
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR014724
Domain description: RNA polymerase Rpb2, OB-fold
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR037033
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007120
Domain description: DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007647
Domain description: RNA polymerase Rpb2, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007646
Domain description: RNA polymerase Rpb2, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007645
Domain description: RNA polymerase Rpb2, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR037034
Domain description: RNA polymerase Rpb2, domain 2 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007642
Domain description: RNA polymerase Rpb2, domain 2
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR007644
Domain description: RNA polymerase, beta subunit, protrusion
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB2
IPR038593
Domain description: RNA polymerase Rpb1, domain 7 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007073
Domain description: RNA polymerase Rpb1, domain 7
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007075
Domain description: RNA polymerase Rpb1, domain 6
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007081
Domain description: RNA polymerase Rpb1, domain 5
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007083
Domain description: RNA polymerase Rpb1, domain 4
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR038120
Domain description: RNA polymerase Rpb1, funnel domain superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR042102
Domain description: RNA polymerase Rpb1, domain 3 superfamily
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007066
Domain description: RNA polymerase Rpb1, domain 3
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR000722
Domain description: RNA polymerase, alpha subunit
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR006592
Domain description: RNA polymerase, N-terminal
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR045867
Domain description: DNA-directed RNA polymerase, subunit beta-prime
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR007080
Domain description: RNA polymerase Rpb1, domain 1
Occurring in:
  1. DNA-directed RNA polymerase II subunit RPB1
IPR040662
Domain description: Transcription factor Tfb2, C-terminal domain
Occurring in:
  1. General transcription factor IIH subunit 4
IPR013087
Domain description: Zinc finger C2H2-type
Occurring in:
  1. General transcription factor IIH subunit 2
IPR046349
Domain description: C1-like domain superfamily
Occurring in:
  1. General transcription factor IIH subunit 2

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