› 5iy3

X-ray diffraction
2.2Å resolution

Zika Virus Non-structural Protein NS1

Released:
DOI: 10.2210/pdb5iy3/pdb
PDB 5iy3 coloured by chain and viewed from the front.
PDB 5iy3 coloured by chain and viewed from the side.
PDB 5iy3 coloured by chain and viewed from the top.
Source organism: Zika virus
Primary publication:
Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses.
Song H, Qi J, Haywood J, Shi Y, Gao GF
Nat. Struct. Mol. Biol. (2016)
PMID: 27088990

Function and Biology Details

Reactions catalysed: 
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Genome polyprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 20.77 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A109PRQ3 (Residues: 966-1146; Coverage: 5%)
Sequence domains: Flavivirus non-structural Protein NS1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 63.868Å b: 103.755Å c: 114.843Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.246
Expression system: Escherichia coli

Quick links

Citations

24 review citations

A Journey to the Central Nervous System: Routes of Flaviviral Neuroinvasion in Human Disease.
Marshall et al. (2022)
23 more

13 mentions without citation

Flavivirus: From Structure to Therapeutics Development.
Zhao et al. (2021)
12 more