› 5ixb

X-ray diffraction
1.39Å resolution

Structure of human Melanoma Inhibitory Activity (MIA) Protein in complex with Pyrimidin-2-amine

Released:
DOI: 10.2210/pdb5ixb/pdb
PDB 5ixb coloured by chain and viewed from the front.
PDB 5ixb coloured by chain and viewed from the side.
PDB 5ixb coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.
Yip KT, Zhong XY, Seibel N, P��tz S, Autzen J, Gasper R, Hofmann E, Scherkenbeck J, Stoll R
Sci Rep 6 25119 (2016)
PMID: 27151361

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Melanoma-derived growth regulatory protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 108 amino acids
Theoretical weight: 12.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16674 (Residues: 25-131; Coverage: 100%)
Gene name: MIA
Sequence domains: Variant SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

2 bound ligands:
Ligand LGA 2 x LGA
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 47.44Å b: 47.48Å c: 87.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.132 0.16
Expression system: Escherichia coli

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Citations

2 citation in other articles

Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin.
Yip et al. (2017)
1 more

1 mention without citation

Small Molecules Antagonise the MIA-Fibronectin Interaction in Malignant Melanoma.
Yip et al. (2016)