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CD47-diabody complex

X-ray diffraction
2.8Å resolution
PDB entry 5iwl coloured by chain, front view.
PDB entry 5iwl coloured by chain, side view.
PDB entry 5iwl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Leukocyte surface antigen CD47 and IG-heavy chain and IG-heavy chain
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Multimeric state: hetero tetramer
Accessible surface area: 29169.47 Å2
Buried surface area: 8962.28 Å2
Dissociation area: 1,672.81 Å2
Dissociation energy (ΔGdiss): -16.98 kcal/mol
Dissociation entropy (TΔSdiss): 24.12 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-211960

Macromolecules

5F9 diabody
Chains: A, B
Length: 234 amino acids
Theoretical weight: 25.51 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
InterPro:
CATH: Immunoglobulins
5F9 diabody in PDB entry 5iwl, assembly 1, front view.
5F9 diabody in PDB entry 5iwl, assembly 1, side view.
5F9 diabody in PDB entry 5iwl, assembly 1, top view.
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Leukocyte surface antigen CD47
Chains: C, D
Length: 114 amino acids
Theoretical weight: 12.86 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q08722 (Residues: 19-132; Coverage: 37%)
Gene names: CD47, MER6
Pfam: CD47 immunoglobulin-like domain
InterPro:
CATH: Immunoglobulins
Leukocyte surface antigen CD47 in PDB entry 5iwl, assembly 1, front view.
Leukocyte surface antigen CD47 in PDB entry 5iwl, assembly 1, side view.
Leukocyte surface antigen CD47 in PDB entry 5iwl, assembly 1, top view.
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