X-ray diffraction
2.7Å resolution

Discovery of imidazoquinolines as a novel class of potent, selective and in vivo efficacious COT kinase inhibitors


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase kinase kinase 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 332 amino acids
Theoretical weight: 37.64 KDa
Source organism: Homo sapiens
  • Canonical: P41279 (Residues: 66-395; Coverage: 71%)
Gene names: COT, ESTF, MAP3K8
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Unit cell:
a: 65.48Å b: 87.43Å c: 125.12Å
α: 90° β: 90° γ: 90°
R R work R free
0.234 0.233 0.258