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Crystal structure of mouse CARM1 in complex with inhibitor SA0765

X-ray diffraction
2.152Å resolution
PDB entry 5ish coloured by chain, front view.
PDB entry 5ish coloured by chain, side view.
PDB entry 5ish coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Histone-arginine methyltransferase CARM1
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Multimeric state: homo tetramer
Accessible surface area: 50531.74 Å2
Buried surface area: 13628.03 Å2
Dissociation area: 1,132.52 Å2
Dissociation energy (ΔGdiss): -7.89 kcal/mol
Dissociation entropy (TΔSdiss): 14.84 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-194407

Macromolecules

Histone-arginine methyltransferase CARM1
Chains: A, B, C, D
Length: 361 amino acids
Theoretical weight: 40.85 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WVG6 (Residues: 130-487; Coverage: 59%)
Gene names: Carm1, Prmt4
Pfam: Ribosomal protein L11 methyltransferase (PrmA)
InterPro:
CATH:
Histone-arginine methyltransferase CARM1 in PDB entry 5ish, assembly 1, front view.
Histone-arginine methyltransferase CARM1 in PDB entry 5ish, assembly 1, side view.
Histone-arginine methyltransferase CARM1 in PDB entry 5ish, assembly 1, top view.
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