› 5iq9

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-229773 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, H
Molecule details ›
Chains: A, H
Length: 232 amino acids
Theoretical weight: 25.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 1-101; Coverage: 25%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
10E8v4 Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 210 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Transmembrane protein gp41 Chains: C, P
Molecule details ›
Chains: C, P
Length: 33 amino acids
Theoretical weight: 4.47 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: Q1HSF8 (Residues: 645-673; Coverage: 3%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 65.025Å b: 79.529Å c: 211.367Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.236
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

12 review citations

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic.
Caskey et al. (2019)
11 more

6 mentions without citation

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Xu et al. (2017)
5 more