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Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with N-((tetrahydrofuran-3-yl)methyl)pyrrolidine-1-carboxamide at 1.93A resolution

X-ray diffraction
1.93Å resolution
PDB entry 5ip6 coloured by chain, front view.
PDB entry 5ip6 coloured by chain, side view.
PDB entry 5ip6 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Ra
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 17148.06 Å2
Buried surface area: 2782.41 Å2
Dissociation area: 1,391.2 Å2
Dissociation energy (ΔGdiss): 15.87 kcal/mol
Dissociation entropy (TΔSdiss): 12.83 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-107750

Macromolecules

HTH tetR-type domain-containing protein
Chain: A
Length: 216 amino acids
Theoretical weight: 23.78 KDa
Source organism: Mycobacterium tuberculosis H37Ra
Expression system: Escherichia coli
UniProt:
  • Canonical: A5U9I4 (Residues: 1-216; Coverage: 100%)
Gene names: MRA_3895, ethR
Pfam:
InterPro:
CATH:
HTH tetR-type domain-containing protein in PDB entry 5ip6, assembly 1, front view.
HTH tetR-type domain-containing protein in PDB entry 5ip6, assembly 1, side view.
HTH tetR-type domain-containing protein in PDB entry 5ip6, assembly 1, top view.
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