PDBe 5il2

X-ray diffraction
1.61Å resolution

Crystal structure of SAH-bound METTL3-METTL14 complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N6-adenosine-methyltransferase catalytic subunit Chain: A
Molecule details ›
Chain: A
Length: 212 amino acids
Theoretical weight: 24.43 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: Q86U44 (Residues: 369-580)
Gene names: METTL3, MTA70
N6-adenosine-methyltransferase non-catalytic subunit Chain: B
Molecule details ›
Chain: B
Length: 300 amino acids
Theoretical weight: 34.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Best match: Q9HCE5 (Residues: 109-408)
Gene names: KIAA1627, METTL14

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P41212
Unit cell:
a: 101.865Å b: 101.865Å c: 115.835Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.185 0.199
Expression system: Spodoptera frugiperda