5ijn

Electron Microscopy
21.4Å resolution

Composite structure of the inner ring of the human nuclear pore complex (32 copies of Nup205)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero 208-mer (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Nuclear pore complex protein Nup155 Chains: A, B, E, K, Q, W
Molecule details ›
Chains: A, B, E, K, Q, W
Length: 1391 amino acids
Theoretical weight: 155.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75694 (Residues: 1-1391; Coverage: 100%)
Gene names: KIAA0791, NUP155
Sequence domains:
Nuclear pore complex protein Nup93 Chains: C, I, O, U
Molecule details ›
Chains: C, I, O, U
Length: 819 amino acids
Theoretical weight: 93.6 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8N1F7 (Residues: 1-819; Coverage: 100%)
Gene names: KIAA0095, NUP93
Sequence domains: Nup93/Nic96
Nuclear pore complex protein Nup205 Chains: D, J, P, V
Molecule details ›
Chains: D, J, P, V
Length: 2012 amino acids
Theoretical weight: 228.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q92621 (Residues: 1-2012; Coverage: 100%)
Gene names: C7orf14, KIAA0225, NUP205
Sequence domains: Nuclear pore complex scaffold, nucleoporins 186/192/205
Nucleoporin p54 Chains: F, L, R, X
Molecule details ›
Chains: F, L, R, X
Length: 507 amino acids
Theoretical weight: 55.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q7Z3B4 (Residues: 1-507; Coverage: 100%)
Gene name: NUP54
Sequence domains:
Nucleoporin p58/p45 Chains: G, M, S, Y
Molecule details ›
Chains: G, M, S, Y
Length: 599 amino acids
Theoretical weight: 60.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BVL2 (Residues: 1-599; Coverage: 100%)
Gene names: KIAA0410, NUP58, NUPL1
Sequence domains: Nucleoporin FG repeated region
Nuclear pore glycoprotein p62 Chains: H, N, T, Z
Molecule details ›
Chains: H, N, T, Z
Length: 522 amino acids
Theoretical weight: 53.29 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P37198 (Residues: 1-522; Coverage: 100%)
Gene name: NUP62
Sequence domains: Nsp1-like C-terminal region

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 21.4Å
Relevant EMDB volumes: EMD-8085
Expression system: Homo sapiens